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Photoimmunotherapy: Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth (Small 46/2020)
Author(s) -
Huang Rongtao,
Ding Zhaoyang,
Jiang BangPing,
Luo Zilan,
Chen Ting,
Guo Zhengxi,
Ji ShiChen,
Liang Hong,
Shen XingCan
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070254
Subject(s) - ovalbumin , metalloprotein , in situ , cancer research , tumor microenvironment , photodynamic therapy , reactive oxygen species , catalysis , chemistry , antigen , enzyme , medicine , tumor cells , biochemistry , immunology , organic chemistry
In article number 2004345, Bang‐Ping Jiang, Xing‐Can Shen, and co‐workers develop one type of brand‐new artificial metalloprotein nanoanalogues for enhanced photoimmunotherapy via reasonably integrating “phototherapy‐enzymatic” RuO 2 and model antigen ovalbumin. This ushers a prospect of concurrently enhancing photodynamic therapy and reversing the immunosuppressive tumor microenvironment by in situ catalyzing overexpressed H 2 O 2 to produce O 2 .