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Superlubricated Microspheres: Ball‐Bearing‐Inspired Polyampholyte‐Modified Microspheres as Bio‐Lubricants Attenuate Osteoarthritis (Small 44/2020)
Author(s) -
Yang Jielai,
Han Ying,
Lin Jiawei,
Zhu Yuan,
Wang Fei,
Deng Lianfu,
Zhang Hongyu,
Xu Xiangyang,
Cui Wenguo
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070238
Subject(s) - microsphere , materials science , lubrication , dispersity , drug delivery , nanotechnology , biomedical engineering , chemical engineering , composite material , polymer chemistry , medicine , engineering
Inspired by the unique structure and lubrication mechanism of ball bearing, monodisperse, size‐uniform hydrogel spheres are fabricated by Hongyu Zhang, Xiangyang Xu, Wenguo Cui, and co‐workers in article number 2004519 using microfluidic technology, and subsequently modified with pSBMA to form superlubricated hydrogel microspheres using a one‐step bionic grafting approach. The superlubricated hydrogel microspheres, with properties of enhanced lubrication and sustained drug release, are used for intra‐articular treatment of osteoarthritis.