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Bioimaging: Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study (Small 37/2020)
Author(s) -
Ding Ling,
Lyu Zhenbin,
Louis Beatrice,
Tintaru Aura,
Laurini Erik,
Marson Domenico,
Zhang Mengjie,
Shao Wanxuan,
Jiang Yifan,
Bouhlel Ahlem,
Balasse Laure,
Garrigue Philippe,
Mas Eric,
Giorgio Suzanne,
Iovanna Juan,
Huang Yuanyu,
Pricl Sabrina,
Guillet Benjamin,
Peng Ling
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070203
Subject(s) - biodistribution , dendrimer , materials science , single photon emission computed tomography , supramolecular chemistry , preclinical imaging , spect imaging , nanotechnology , in vivo , nuclear medicine , chemistry , medicine , polymer chemistry , crystallography , in vitro , microbiology and biotechnology , crystal structure , biology , biochemistry
In article number 2003290, Ling Peng and co‐workers report a self‐assembling supramolecular dendrimer probe for tumor imaging by single photon emission computed tomography (SPECT). Altering the radionuclide chelators on the dendrimer surface leads to a highly favorable biodistribution profile with a drastically reduced uptake in liver and a significantly improved tumor imaging contrast.