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Phenome–Genome Profiling: Phenome–Genome Profiling of Single Bacterial Cell by Raman‐Activated Gravity‐Driven Encapsulation and Sequencing (Small 30/2020)
Author(s) -
Xu Teng,
Gong Yanhai,
Su Xiaolu,
Zhu Pengfei,
Dai Jing,
Xu Jian,
Ma Bo
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070165
Subject(s) - phenome , genome , biology , computational biology , whole genome sequencing , gene , genetics
In article number 2001172, Jian Xu, Bo Ma, and co‐workers invent Raman‐activated gravity‐driven single‐cell encapsulation and sequencing (RAGE‐Seq). It produces antimicrobial susceptibility phenotypes and the genome sequence of 99.5% coverage simultaneously from precisely one bacterial cell. The ability to profile and correlate the microbial metabolic phenome and high‐quality genomes at one‐cell resolution has broad implications in clinical medicine.