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Angiogenesis: Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP‐Mediated Mechanosensing (Small 25/2020)
Author(s) -
Bandaru Praveen,
Cefaloni Giorgia,
Vajhadin Fereshteh,
Lee KangJu,
Kim HanJun,
Cho HyunJong,
Hartel Martin C.,
Zhang Shiming,
Sun Wujin,
Goudie Marcus J.,
Ahadian Samad,
Dokmeci Mehmet Remzi,
Lee Junmin,
Khademhosseini Ali
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070142
Subject(s) - mesenchymal stem cell , angiogenesis , microbiology and biotechnology , stem cell , mechanotransduction , secretion , chemistry , biology , cancer research , biochemistry
In article number 2001837, Junmin Lee, Ali Khademhosseini, and co‐workers develop a bioreactor‐based platform to investigate the effect of human mesenchymal stem cell (hMSC) culture microenvironments including matrix rigidity and dynamic mechanical compression on their secretion level of pro‐angiogenic factors. It is demonstrated that these mechanical cues regulate pro‐angiogenic potential of hMSCs through yes‐associated protein (YAP)‐mediated mechanosensing.