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Organ‐On‐A‐Chip Systems: Human‐on‐Leaf‐Chip: A Biomimetic Vascular System Integrated with Chamber‐Specific Organs (Small 22/2020)
Author(s) -
Mao Mao,
Bei Ho Pan,
Lam Chun Hei,
Chen Pengyu,
Wang Shuqi,
Chen Ying,
He Jiankang,
Zhao Xin
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070124
Subject(s) - organ on a chip , crosstalk , chip , organ system , nanotechnology , in vivo , biomedical engineering , materials science , biology , computer science , medicine , pathology , engineering , microfluidics , microbiology and biotechnology , telecommunications , disease , electronic engineering
In article number 2000546, Jiankang He, Xin Zhao, and co‐workers report a human‐on‐leaf#x02010;chip system with biomimetic multiscale vasculature systems connecting vascularized organs, mimicking the complex in vivo architectures of the human cardiovascular system. The native organ‐to‐organ crosstalk is well recapitulated, implicating a strong potential for harnessing the leaf chip for circulatory‐related studies such as metastasis.