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Nanoparticle Interactions: Mass Cytometry and Single‐Cell RNA‐seq Profiling of the Heterogeneity in Human Peripheral Blood Mononuclear Cells Interacting with Silver Nanoparticles (Small 21/2020)
Author(s) -
Ha My Kieu,
Kwon Sook Jin,
Choi JangSik,
Nguyen Nguyen Thanh,
Song Jaewoo,
Lee Yangsoon,
Kim YoungEun,
Shin Incheol,
Nam JinWu,
Yoon Tae Hyun
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202070114
Subject(s) - mass cytometry , peripheral blood mononuclear cell , cell , flow cytometry , immune system , transcriptome , single cell analysis , rna , cytometry , cell type , nanoparticle , microbiology and biotechnology , computational biology , chemistry , biology , phenotype , nanotechnology , immunology , materials science , gene expression , biochemistry , in vitro , gene
In article number 1907674, Tae Hyun Yoon and co‐workers report complementary use of single‐cell based mass cytometry and RNA‐seq techniques for the analysis of the heterogeneous interaction between nanoparticles and human immune cells at a single‐cell level, via the identification of various immune cell types, quantification of cell‐associated nanoparticles, and observation of the changes in transcriptomic profiles and signaling protein expressions.