Premium
Photosynthetic Microorganisms‐Based Biophotothermal Therapy with Enhanced Immune Response
Author(s) -
Wang Haoran,
Guo Yunfei,
Gan Shaoju,
Liu Honghui,
Chen Qian,
Yuan Ahu,
Hu Yiqiao,
Wu Jinhui
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007734
Subject(s) - photothermal therapy , in vivo , immune system , photosynthesis , cancer research , in vitro , abscopal effect , immunotherapy , chemistry , biology , materials science , nanotechnology , immunology , biochemistry , microbiology and biotechnology
The production of oxygen by photosynthetic microorganisms (PSMs) has recently attracted interest concerning the in vivo treatment of multiple diseases for their photosynthetic oxygen production in vivo, since PSMs have good biological safety. Here, the first evidence that PSMs can be used as a photothermal source to perform biophotothermal therapy (bio‐PTT) is provided. In vitro and in vivo experiments proved that PSMs can generate heat for the direct elimination of tumors and release a series of pathogen‐associated molecular patterns and adjuvants for immune stimulation under light irradiation. Bio‐PTT enabled a local tumor inhibition rate exceeding 90% and an abscopal tumor inhibition rate exceeding 75%. This strategy also produced a stronger antitumor immune memory effect to prevent tumor recurrence. The bio‐PTT strategy provides a novel direction for photothermal therapy as it simultaneously produces local and abscopal antitumor effects.