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Nanochemistry Modulates Intracellular Decomposition Routes of S‐Nitrosothiol Modified Silica‐Based Nanoparticles
Author(s) -
Theivendran Shevanuja,
Yu Chengzhong
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007671
Subject(s) - nanochemistry , intracellular , decomposition , nanoparticle , glutathione , mesoporous silica , nanotechnology , materials science , nitric oxide , combinatorial chemistry , chemistry , catalysis , mesoporous material , organic chemistry , biochemistry , enzyme
Abstract Cellular delivery of nitric oxide (NO) using NO donor moieties such as S‐nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH 3 ) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH 3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.