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Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy
Author(s) -
Zhou Zhan,
Wang Xianwen,
Zhang Hui,
Huang Haoxin,
Sun Lina,
Ma Lu,
Du Yonghua,
Pei Chengjie,
Zhang Qinghua,
Li Hai,
Ma Lufang,
Gu Lin,
Liu Zhuang,
Cheng Liang,
Tan Chaoliang
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007486
Subject(s) - photothermal therapy , materials science , nanomaterials , biocompatibility , nanotechnology , absorption (acoustics) , composite material , metallurgy
Layered metal oxides including MoO 3 and WO 3 have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near‐infrared (NIR) absorption and thus are inefficient for photo‐induced biomedical applications. Herein, the structural engineering of layered MoO 3 and WO 3 nanostructures is first reported to activate their NIR‐II absorption for efficient photothermal cancer therapy in the NIR‐II window. White‐colored micrometre‐long MoO 3 nanobelts are transformed into blue‐colored short, thin, defective, interlayer gap‐expanded MoO 3− x nanobelts with a strong NIR‐II absorption via the simple lithium treatment. The blue MoO 3− x nanobelts exhibit a large extinction coefficient of 18.2 L g −1 cm −1 and high photothermal conversion efficiency of 46.9% at 1064 nm. After surface modification, the MoO 3− x nanobelts can be used as a robust nanoagent for photoacoustic imaging‐guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication under irradiation by a 1064 nm laser. Importantly, the biodegradable MoO 3− x nanobelts can be rapidly degraded and excreted from body. The study highlights that the structural engineering of layered metal oxides is a powerful strategy to tune their properties and thus boost their performances in given applications.