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Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells
Author(s) -
Zhou Zhixin,
Fan Daoqing,
Wang Jianbang,
Sohn Yang Sung,
Nechushtai Rachel,
Willner Itamar
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007355
Subject(s) - trimer , tetrahedron , dimer , monomer , dna , materials science , crystallography , chemistry , nanotechnology , polymer , organic chemistry , biochemistry
The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K + ‐ion‐stabilized G‐quadruplexes or T‐A • T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal‐triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA‐sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.