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Dilation‐Responsive Microshape Programing Prevents Vascular Graft Stenosis
Author(s) -
Yi Se Won,
Shin Young Min,
Lee Jung Bok,
Park Ju Young,
Kim DaeHyun,
Baek Wooyeol,
Yoon JeongKee,
Kim Deok Gie,
Shin In Sik,
Kim ChangSoo,
Kang MiLan,
Yang Jae Won,
Sung HakJoon
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007297
Subject(s) - vasa vasorum , dilation (metric space) , adventitia , stenosis , microscale chemistry , artery , vein , vascular smooth muscle , materials science , medicine , cardiology , anatomy , biomedical engineering , surgery , smooth muscle , psychology , mathematics , combinatorics , mathematics education
Shape memory materials have been successfully applied to minimally invasive implantation of medical devices. However, organ‐movement‐specific shape programing at a microscale level has never been demonstrated despite significant unmet needs. As vein‐to‐artery grafting induces vein dilation and stenosis, a polymeric self‐enclosable external support (SES) is designed to wrap the vascular out‐wall. Its micropores are programmed to increase sizes and interconnections upon dilation. Vessel dilation promotes venous maturation, but overdilation induces stenosis by disturbed blood flow. Therefore, the unique elastic shape‐fixity of SES provides a foundation to enable a stable microscale shape transition by maintaining the vein dilation. The shape transition of micropore architecture upon dilation induces beneficial inflammation, thereby regenerating vasa vasorum and directing smooth muscle cell migration toward adventitia with the consequent muscle reinforcement of veins. This game‐changer approach prevents the stenosis of vein‐to‐artery grafting by rescuing ischemic disorders and promoting arterial properties of veins.