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A Photoresponsive Nanozyme for Synergistic Catalytic Therapy and Dual Phototherapy
Author(s) -
Yang Hailong,
Xu Bolong,
Li Shanshan,
Wu Qingyuan,
Lu Mingzhu,
Han Along,
Liu Huiyu
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202007090
Subject(s) - photothermal therapy , photodynamic therapy , tumor hypoxia , hydrogen peroxide , chemistry , radical , catalysis , tumor microenvironment , reactive oxygen species , catalase , peroxidase , cancer therapy , photothermal effect , biophysics , photochemistry , cancer research , nanotechnology , materials science , tumor cells , enzyme , radiation therapy , cancer , biochemistry , organic chemistry , medicine , biology
Dual phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has shown a great prospect in cancer treatment. However, its therapeutic effect is restricted by the depth of light penetration in tissue and tumor hypoxia environment. Herein, inspired by the specific response of nanozymes to the tumor microenvironment (TME), a simple and versatile nanozyme‐mediated synergistic dual phototherapy nanoplatform (denoted as FePc/HNCSs) is constructed using hollow nitrogen‐doped carbon nanospheres (HNCSs) and iron phthalocyanine (FePc). FePc/HNCSs simultaneously exhibit peroxidase (POD)‐ and catalase (CAT)‐like activities, which not only can convert endogenous hydrogen peroxide (H 2 O 2 ) into highly toxic hydroxyl radicals (•OH) for catalytic therapy, but also decompose H 2 O 2 to oxygen (O 2 ) to enhance O 2 ‐dependent PDT. In addition, their enzyme‐like activities are significantly enhanced under light irradiation. Combining with the excellent photothermal effect, FePc/HNCSs realize a high tumor inhibition rate of 96.3%. This strategy opens a new horizon for exploring a more powerful tumor treatment nanoplatform.