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A Multichannel Flexible Optoelectronic Fiber Device for Distributed Implantable Neurological Stimulation and Monitoring
Author(s) -
Yu Jingxian,
Ling Wei,
Li Ya,
Ma Ning,
Wu Ziyue,
Liang Rong,
Pan Huizhuo,
Liu Wentao,
Fu Bo,
Wang Kun,
Li Chenxi,
Wang Hanjie,
Peng Hui,
Ning Baoan,
Yang Jiajia,
Huang Xian
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202005925
Subject(s) - flexible electronics , materials science , electronics , optical fiber , microelectrode , bioelectronics , flexibility (engineering) , optical switch , electronic circuit , computer science , electronic component , optoelectronics , nanotechnology , electrode , biosensor , electrical engineering , telecommunications , physics , engineering , quantum mechanics , statistics , mathematics
Optical fibers made of polymeric materials possess high flexibility that can potentially integrate with flexible electronic devices to realize complex functions in biology and neurology. Here, a multichannel flexible device based on four individually addressable optical fibers transfer‐printed with flexible electronic components and controlled by a wireless circuit is developed. The resulting device offers excellent mechanics that is compatible with soft and curvilinear tissues, and excellent diversity through switching different light sources. The combined configuration of optical fibers and flexible electronics allows optical stimulation in selective wavelengths guided by the optical fibers, while conducting distributed, high‐throughput biopotential sensing using the flexible microelectrode arrays. The device has been demonstrated in vivo with rats through optical stimulation and simultaneously monitoring of spontaneous/evoked spike signals and local field potentials using 32 microelectrodes in four brain regions. Biocompatibility of the device has been characterized by behavior and immunohistochemistry studies, demonstrating potential applications of the device in long‐term animal studies. The techniques to integrate flexible electronics with optical fibers may inspire the development of more flexible optoelectronic devices for sophisticated applications in biomedicine and biology.