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Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration
Author(s) -
Cheng Liang,
Chen Zhijie,
Cai Zhengwei,
Zhao Jingwen,
Lu Min,
Liang Jing,
Wang Fei,
Qi Jin,
Cui Wenguo,
Deng Lianfu
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202005433
Subject(s) - biomineralization , regeneration (biology) , osteoblast , scaffold , bone morphogenetic protein 2 , electrospinning , bone healing , materials science , biocompatibility , bone tissue , microbiology and biotechnology , chemistry , biomedical engineering , anatomy , in vitro , biochemistry , biology , composite material , medicine , metallurgy , polymer , paleontology
Abstract The ideal bone repair material should firstly recognize and recruit osteoblast precursor cells to initiate the repair process, then promote the differentiation of osteoblasts and accelerate the mineralization of the extracellular matrix (ECM). Here, a bioinspired staged bone regeneration strategy which loads bone morphogenetic protein 2 (BMP 2 )‐modified black phosphorus (BP@BMP 2 ) nanosheets to a polylactic acid (PLLA) electrospun fibrous scaffold, with a combination of recruiting osteoblast precursor cells and biomineralization properties for bone regeneration, is constructed successfully by micro‐sol electrospinning technique. BP, acting as carriers, can not only provide a negative surface and a strong BMP 2 loading ability but can also promote biomineralization in a 3D manner on the electrospun fibrous scaffold, while the BMP 2 is to target osteoblast precursor cells for recruitment and osteogenesis differentiation, which endows BP@BMP 2 nanosheets with staged bone regeneration ability. Furthermore, the in vitro and in vivo data showed that the BP@BMP 2 loaded electrospun fibrous scaffold have good biocompatibility and a strong osteogenesis ability resulting in rapid new bone tissue regeneration. Altogether, this newly developed bioinspired BMP 2 ‐modified BP electrospun fiber with staged bone regeneration properties via recruiting osteoblast precursor cells to the bone injured site and accelerating biomineralization can be a promising approach in physiologic bone repair.