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Principles and Applications of Single Particle Tracking in Cell Research
Author(s) -
Wang Zhao,
Wang Xuejing,
Zhang Ying,
Xu Weili,
Han Xiaojun
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202005133
Subject(s) - internalization , tracking (education) , decipher , nanotechnology , organelle , intracellular , particle (ecology) , cell , biological system , computer science , materials science , chemistry , biology , microbiology and biotechnology , bioinformatics , psychology , ecology , pedagogy , biochemistry
It is a tough challenge for many decades to decipher the complex relationships between cell behaviors and cellular physical properties. Single particle tracking (SPT) with high spatial and temporal resolution has been applied extensively in cell research to understand physicochemical properties of cells and their bio‐functions by tracking endogenous or exogenous probes. This review describes the fundamental principles of SPT as well as its applications in intracellular mechanics, membrane dynamics, organelles distribution, and processes of internalization and transport. Finally, challenges and future directions of SPT are also discussed.