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Multidimensional Anisotropic Architectures on Polymeric Microparticles
Author(s) -
Agusil Juan Pablo,
Arjona María Isabel,
Duch Marta,
Fusté Naüm,
Plaza José A.
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202004691
Subject(s) - microscale chemistry , nanotechnology , miniaturization , anisotropy , materials science , lithography , photolithography , fabrication , isotropic etching , etching (microfabrication) , optoelectronics , optics , physics , medicine , mathematics education , mathematics , alternative medicine , pathology , layer (electronics)
Next generation life science technologies will require the integration of building blocks with tunable physical and chemical architectures at the microscale. A central issue is to govern the multidimensional anisotropic space that defines these microparticle attributes. However, this control is limited to one or few dimensions due to profound fabrication tradeoffs, a problem that is exacerbated by miniaturization. Here, a vast number of anisotropic dimensions are integrated combining SU‐8 photolithography with (bio)chemical modifications via soft‐lithography. Microparticles in a 15‐D anisotropic space are demonstrated, covering branching, faceting, fiducial, topography, size, aspect ratio, stiffness, (bio)molecular and quantum dot printing, top/bottom surface coverage, and quasi‐ 0D, 1D, 2D, and 3D surface patterning. The strategy permits controlled miniaturization on physical dimensions below 1 µm and molecular patterns below 1 µm 2 . By combining building blocks, anisotropic microparticles detect pH changes, form the basis for a DNA‐assay recognition platform, and obtain an extraordinary volumetric barcoding density up to 1093 codes µm −3 in a 3 × 12 × 0.5 µm 3 volume.