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A pH‐Responsive Polymer‐CeO 2 Hybrid to Catalytically Generate Oxidative Stress for Tumor Therapy
Author(s) -
Tian Zhimin,
Liu Hongbao,
Guo Zhixiong,
Gou Wangyan,
Liang Zechen,
Qu Yongquan,
Han Lili,
Liu Lei
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202004654
Subject(s) - nanorod , catalysis , reactive oxygen species , oxidative stress , tumor microenvironment , nanoreactor , polymer , materials science , oxygen , polystyrene , oxidative phosphorylation , chemistry , biophysics , nanotechnology , tumor cells , biochemistry , cancer research , organic chemistry , biology
Catalytic generation of reactive oxygen species has been developed as a promising methodology for tumor therapy. Direct O 2 •− production from intratumor oxygen exhibits exceptional tumor therapeutic efficacy. Herein, this therapy strategy is demonstrated by a pH‐responsive hybrid of porous CeO 2 nanorods and sodium polystyrene sulfonate that delivers high oxidative activity for O 2 •− generation within acidic tumor microenvironments for chemodynamic therapy and only limited oxidative activity in neutral media to limit damage to healthy organs. The hydrated polymer–nanorod hybrids with large hydrodynamic diameters form nanoreactors that locally trap oxygen and biological substrates inside and improve the charge transfer between the catalysts and substrates in the tumor microenvironment, leading to enhanced catalytic O 2 •− production and consequent oxidation. Together with successful in vitro and in vivo experiments, these data show that the use of hybrids provides a compelling opportunity for the delivery selective chemodynamic tumor therapy.