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Zirconia Hybrid Nanoshells for Nutrient and Toxin Detection
Author(s) -
Rana Md Sohel,
Xu Lin,
Cai Jingyi,
Vedarethinam Vadanasundari,
Tang Yuanjia,
Guo Qiang,
Huang Hongtao,
Shen Nan,
Di Wen,
Ding Huihua,
Huang Lin,
Qian Kun
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202003902
Subject(s) - nanoshell , analyte , detection limit , materials science , nanotechnology , mass spectrometry , bioanalysis , cubic zirconia , sample preparation , chromatography , chemistry , nanoparticle , ceramic , composite material
Monitoring milk quality is of fundamental importance in food industry, because of the nutritional value and resulting position of milk in daily diet. The detection of small nutrients and toxins in milk is challenging, considering high sample complexity and low analyte abundance. In addition, the slow analysis and tedious sample preparation hinder the large‐scale application of conventional detection techniques. Herein, zirconia hybrid nanoshells are constructed to enhance the performance of laser desorption/ionization mass spectrometry (LDI MS). Zirconia nanoshells with the optimized structures and compositions are used as matrices in LDI MS and achieve direct analysis of small molecules from 5 nL of native milk in ≈1 min, without any purification or separation. Accurate quantitation of small nutrient is achieved by introducing isotope into the zirconia nanoshell‐assisted LDI MS as the internal standard, offering good consistency to biochemical analysis (BCA) with R 2 = 0.94. Further, trace toxin is enriched and identified with limit‐of‐detection (LOD) down to 4 p m , outperforming the current analytical methods. This work sheds light on the personalized design of material‐based tool for real‐case bioanalysis and opens up new opportunities for the simple, fast, and cost‐effective detection of various small molecules in a broad field.