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Gold Nanoclusters for NIR‐II Fluorescence Imaging of Bones
Author(s) -
Li Deling,
Liu Qiang,
Qi Qingrong,
Shi Hui,
Hsu EnChi,
Chen Weiyu,
Yuan Wenli,
Wu Yifan,
Lin Sien,
Zeng Yitian,
Xiao Zunyu,
Xu Lingyun,
Zhang Yanrong,
Stoyanova Tanya,
Jia Wang,
Cheng Zhen
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202003851
Subject(s) - nanoclusters , fluorescence , fluorescence lifetime imaging microscopy , materials science , near infrared spectroscopy , in vivo , biomedical engineering , preclinical imaging , nanotechnology , medicine , optics , biology , physics , microbiology and biotechnology
Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) holds great promise for deep tissue visualization. Development of novel clinical translatable NIR‐II probes is crucial for realizing the medical applications of NIR‐II fluorescence imaging. Herein, the glutathione‐capped gold nanoclusters (AuNCs, specifically Au 25 (SG) 18 ) demonstrate highly efficient binding capability to hydroxyapatite in vitro for the first time. Further in vivo NIR‐II fluorescence imaging of AuNCs indicate that they accumulate in bone tissues with high contrast and signal‐background ratio. AuNCs are also mainly and quickly excreted from body through renal system, showing excellent ribs and thoracic vertebra imaging because of no background signal in liver and spleen. The deep tissue penetration capability and high resolution of AuNCs in NIR‐II imaging render their great potential for fluorescence‐guided surgery like spinal pedicle screw implantation. Overall, AuNCs are highly promising and clinical translatable NIR‐II imaging probe for visualizing bone and bone related abnormalities.