Premium
Oxygen‐Deficient Bimetallic Oxide FeWO X Nanosheets as Peroxidase‐Like Nanozyme for Sensing Cancer via Photoacoustic Imaging
Author(s) -
Gong Fei,
Yang Nailin,
Wang Yong,
Zhuo Mingpeng,
Zhao Qi,
Wang Sheng,
Li Yonggang,
Liu Zhuang,
Chen Qian,
Cheng Liang
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202003496
Subject(s) - bimetallic strip , catalysis , radical , hydrogen peroxide , materials science , chemistry , thermal decomposition , decomposition , oxide , organic chemistry
Nanozymes with high catalytic activity and great stability have attracted increasing interests as the promising alternative to natural enzymes for applications in various fields. In this study, a new type of highly efficient peroxidase‐like nanozymes based on FeWO X nanosheets (NSs) synthesized by a thermal‐decomposition method is reported. Owing to the sheet‐structure with maximized utilization of catalytic sites (Fe atoms and oxygen vacancies), such FeWO X NSs exert efficient enzyme activity to trigger catalytic decomposition of hydrogen peroxide (H 2 O 2 ) into hydroxyl radicals (•OH). A nanozyme‐based ratio‐metric nanoprobe is then fabricated by co‐loading of 3,3,5,5‐tetramethylbenzidine (TMB) and IR780 dye on FeWO X NSs to enable ratio‐metric photoacoustic (PA) imaging of endogenous H 2 O 2 , as verified by imaging of the subcutaneous 4T1 xenograft tumor model and lipopolysaccharide (LPS)‐induced inflammation model. Moreover, FeWO X NSs could also be employed as promising nanoagents for multimodal computed tomography (CT) and magnetic resonance (MR) imaging of tumors, due to the strong X‐ray attenuation ability of W element and high MR contrast ability of Fe element, respectively. Importantly, FeWO X NSs with good biodegradability could be cleared out from the body without any significant biotoxicity. This work highlights bimetallic oxide FeWO X NSs as an enzyme‐mimetic nanoplatform for imaging of the tumor microenvironment.