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Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study
Author(s) -
Ding Ling,
Lyu Zhenbin,
Louis Beatrice,
Tintaru Aura,
Laurini Erik,
Marson Domenico,
Zhang Mengjie,
Shao Wanxuan,
Jiang Yifan,
Bouhlel Ahlem,
Balasse Laure,
Garrigue Philippe,
Mas Eric,
Giorgio Suzanne,
Iovanna Juan,
Huang Yuanyu,
Pricl Sabrina,
Guillet Benjamin,
Peng Ling
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202003290
Subject(s) - biodistribution , nanoprobe , context (archaeology) , dendrimer , nanotechnology , amphiphile , chemistry , zeta potential , preclinical imaging , supramolecular chemistry , spect imaging , materials science , surface charge , nanoparticle , biophysics , in vivo , nuclear medicine , in vitro , medicine , crystallography , biochemistry , organic chemistry , paleontology , microbiology and biotechnology , crystal structure , biology , copolymer , polymer
Bioimaging has revolutionized medicine by providing accurate information for disease diagnosis and treatment. Nanotechnology‐based bioimaging is expected to further improve imaging sensitivity and specificity. In this context, supramolecular nanosystems based on self‐assembly of amphiphilic dendrimers for single photon emission computed tomography (SPECT) bioimaging are developed. These dendrimers bear multiple In 3+ radionuclides at their terminals as SPECT reporters. By replacing the macrocyclic 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid cage with the smaller 1,4,7‐triazacyclononane‐1,4,7‐triacetic acid scaffold as the In 3+ chelator, the corresponding dendrimer exhibits neutral In 3+ ‐complex terminals in place of negatively charged In 3+ ‐complex terminals. This negative‐to‐neutral surface charge alteration completely reverses the zeta‐potential of the nanosystems from negative to positive. As a consequence, the resulting SPECT nanoprobe generates a highly sought‐after biodistribution profile accompanied by a drastically reduced uptake in liver, leading to significantly improved tumor imaging. This finding contrasts with current literature reporting that positively charged nanoparticles have preferential accumulation in the liver. As such, this study provides new perspectives for improving the biodistribution of positively charged nanosystems for biomedical applications.