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Chemotaxis‐Driven 2D Nanosheet for Directional Drug Delivery toward the Tumor Microenvironment
Author(s) -
Zhang Hao,
Cao Zhenbang,
Zhang Qianyi,
Xu Jiangtao,
Yun Sung Lai Jimmy,
Liang Kang,
Gu Zi
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202002732
Subject(s) - nanosheet , chemotaxis , drug delivery , tumor microenvironment , nanotechnology , drug , microbiology and biotechnology , materials science , cancer research , chemistry , receptor , tumor cells , biology , pharmacology , biochemistry
Abstract Micro/nanoscaled motor particles represent a group of intelligent materials that can precisely and rapidly respond to biological microenvironments and improve therapeutic outcomes. In order to maximize biomedical application potentials, developing a nanoscaled motor particle that is able to move autonomously toward a biological target is highly desired but still remains a critical challenge. Herein, a 2D nanosheet‐based catalytic nanomotor with chemotaxis behavior is developed for enhanced drug delivery toward the tumor microenvironment. The nanomotors are constructed via a facile one‐pot method and exhibit ultrathin monolayer nanosheet morphology. The 2D structure of nanomotors allows high catalytic activity, leading to responsive, sustained, and relatively long distance movement. Importantly, this nanomotor demonstrates directional motion toward the high gradient of H 2 O 2 fuel, exhibiting excellent chemotactic properties. After loading an anticancer drug doxorubicin, the nanomotor shows effective inhibition on cancer cell growth in simulated tumor microenvironments. The practical drug delivery application is further strengthened by the intracellular acidity‐triggered biodegradability of the nanomotor after accomplishing the directional drug delivery function. This proof‐of‐concept work highlights the efficient catalytic activity, tumor microenvironment‐guided chemotactic movement, excellent cellular performance of the 2D nanomotor, and opens an avenue for biomedical applications such as controlled and smart drug delivery.