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Core–Shell–Satellite Nanomaces as Remotely Controlled Self‐Fueling Fenton Reagents for Imaging‐Guided Triple‐Negative Breast Cancer‐Specific Therapy
Author(s) -
Du Yang,
Yang Chuang,
Li Fangyuan,
Liao Hongwei,
Chen Zheng,
Lin Peihua,
Wang Nan,
Zhou Yan,
Lee Ji Young,
Ding Qiang,
Ling Daishun
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202002537
Subject(s) - triple negative breast cancer , reagent , chemistry , nanorod , cancer research , fenton reaction , intracellular , biophysics , breast cancer , materials science , nanotechnology , cancer , biochemistry , medicine , hydrogen peroxide , biology
Triple‐negative breast cancer (TNBC) is highly aggressive and insensitive to conventional targeted therapies, resulting in poor therapeutic outcomes. Recent studies have shown that abnormal iron metabolism is observed in TNBC, suggesting an opportunity for TNBC treatment via the iron‐dependent Fenton reaction. Nevertheless, the efficiency of current Fenton reagents is largely restricted by the lack of specificity and low intracellular H 2 O 2 level of cancer cells. Herein, core–shell–satellite nanomaces (Au @ MSN@IONP) are fabricated, as near‐infrared (NIR) light‐triggered self‐fueling Fenton reagents for the amplified Fenton reaction inside TNBC cells. Specifically, the Au nanorod core can convert NIR light energy into heat to induce massive production of intracellular H 2 O 2 , thereby the surface‐decorated iron oxide nanoparticles (IONP) are being fueled for robust Fenton reaction. By exploiting the vulnerability of iron efflux in TNBC cells, such a self‐fueling Fenton reaction leads to highly specific anti‐TNBC efficacy with minimal cytotoxicity to normal cells. The PI3K/Akt/FoxO axis, intimately involved in the redox regulation and survival of TNBC, is demonstrated to be inhibited after the treatment. Consequently, precise in vivo orthotopic TNBC ablation is achieved under the guidance of IONP‐enhanced magnetic resonance imaging. The results demonstrate the proof‐of‐concept of NIR‐light‐triggered self‐fueling Fenton reagents against TNBC with low ferroportin levels.