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Engineering Inorganic Nanoflares with Elaborate Enzymatic Specificity and Efficiency for Versatile Biofilm Eradication
Author(s) -
Liang Meijuan,
Wang Yanbing,
Ma Kang,
Yu Shanshan,
Chen Yingying,
Deng Zhao,
Liu Yi,
Wang Fuan
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202002348
Subject(s) - nanotechnology , biosensor , biofilm , materials science , hydrogen peroxide , substrate (aquarium) , combinatorial chemistry , chemistry , bacteria , biology , biochemistry , genetics , ecology
Nanozyme has emerged as a versatile nanocatalyst yet is constrained with limited catalytic efficiency and specificity for various biomedical applications. Herein, by elaborately integrating the recognition/transduction carbon dots (CDs) with platinum nanoparticles (PtNPs), an exquisite CDs@PtNPs (CPP) nanoflare is engineered as an efficient and substrate‐specific peroxidase‐mimicking nanozyme for high‐performance biosensing and antibacterial applications. The intelligent CPP‐catalyzed hydrogen peroxide (H 2 O 2 )‐generated reactive oxygen species realize the sensitive diagnosis‐guided enhanced disinfection of pathogens. Significantly, the CPP nanozyme shows the prominent biofilm eradication and wound healing in vivo by virtue of endogenous H 2 O 2 in acidic infection tissues, which can substantially preclude the annoying antibiotics resistance. A fundamental understanding on the present CPP nanoflare would not only facilitate the advancement of various prospective biocatalysts, but also establish a multifunctional means for versatile biosensing and smart diagnostic applications.