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Nano Assessing Nano: Nanosensor‐Enabled Detection of Cell Phenotypic Changes Identifies Nanoparticle Toxicological Effects at Ultra‐Low Exposure Levels
Author(s) -
Geng Yingying,
Chattopadhyay Aritra Nath,
Zhang Xianzhi,
Jiang Mingdi,
Luther David C.,
Gopalakrishnan Sanjana,
Rotello Vincent M.
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202002084
Subject(s) - nanotoxicology , nanosensor , nanomaterials , nano , nanotechnology , phenotype , nanoparticle , materials science , chemistry , composite material , gene , biochemistry
Abstract Industrial use of nanomaterials is rapidly increasing, making the effects of these materials on the environment and human health of critical concern. Standard nanotoxicity evaluation methods rely on detecting cell death or major dysfunction and will miss early signs of toxicity. In this work, the use of rapid and sensitive nanosensors that can efficiently detect subtle phenotypic changes on the cell surface following nanomaterial exposure is reported. Importantly, the method reveals significant phenotypic changes at dosages where other conventional methods show normal cellular activity. This approach holds promise in toxicological and pharmacological evaluations to ensure safer and better use of nanomaterials.