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New Insights into Biocompatible Iron Oxide Nanoparticles: A Potential Booster of Gene Delivery to Stem Cells
Author(s) -
Zhang Tianyuan,
Xu Qianhao,
Huang Ting,
Ling Daishun,
Gao Jianqing
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202001588
Subject(s) - gene delivery , stem cell , biocompatible material , nanotechnology , iron oxide nanoparticles , biocompatibility , materials science , genetic enhancement , chemistry , nanoparticle , biology , medicine , biomedical engineering , microbiology and biotechnology , gene , biochemistry , metallurgy
Gene delivery to stem cells is a critical issue of stem cells‐based therapies, still facing ongoing challenges regarding efficiency and safety. Recent advances in the controlled synthesis of biocompatible magnetic iron oxide nanoparticles (IONPs) have provided a powerful nanotool for assisting gene delivery to stem cells. However, this field is still at an early stage, with well‐designed and scalable IONPs synthesis highly desired. Furthermore, the potential risks or bioeffects of IONPs on stem cells are not completely figured out. Therefore, in this review, the updated researches focused on the gene delivery to stem cells using various designed IONPs are highlighted. Additionally, the impacts of the physicochemical properties of IONPs, as well as the magnetofection systems on the gene delivery performance and biocompatibility are summarized. Finally, challenges attributed to the potential impacts of IONPs on the biologic behaviors of stem cells and the large‐scale productions of uniform IONPs are emphasized. The principles and challenges summarized in this review provide a general guidance for the rational design of IONPs‐assisted gene delivery to stem cells.