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In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy
Author(s) -
Hu WenChao,
Younis Muhammad Rizwan,
Zhou Yue,
Wang Chen,
Xia XingHua
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202000553
Subject(s) - biocompatibility , nanotechnology , antibacterial activity , nanoparticle , nanomaterials , materials science , staphylococcus aureus , in situ , combinatorial chemistry , chemistry , bacteria , organic chemistry , biology , genetics , metallurgy
As one of the common reactive oxygen species, H 2 O 2 has been widely used for combating pathogenic bacterial infections. However, the high dosage of H 2 O 2 can induce undesired damages to normal tissues and delay wound healing. In this regard, peroxidase‐like nanomaterials serve as promising nanozymes, thanks to their positive promotion toward the antibacterial performance of H 2 O 2 , while avoiding the toxicity caused by the high concentrations of H 2 O 2 . In this work, ultrasmall Au nanoparticles (UsAuNPs) are grown on ultrathin 2D metal–organic frameworks (MOFs) via in situ reduction. The formed UsAuNPs/MOFs hybrid features both the advantages of UsAuNPs and ultrathin 2D MOFs, displaying a remarkable peroxidase‐like activity toward H 2 O 2 decomposition into toxic hydroxyl radicals (·OH). Results show that the as‐prepared UsAuNPs/MOFs nanozyme exhibits excellent antibacterial properties against both Gram‐negative ( Escherichia coli ) and Gram‐positive ( Staphylococcus aureus ) bacteria with the assistance of a low dosage of H 2 O 2 . Animal experiments indicate that this hybrid material can effectively facilitate wound healing with good biocompatibility. This study reveals the promising potential of a hybrid nanozyme for antibacterial therapy and holds great promise for future clinical applications.