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Microcirculation‐on‐Chip: Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution (Small 46/2019)
Author(s) -
Offeddu Giovanni S.,
Possenti Luca,
LoessbergZahl Joshua T.,
Zunino Paolo,
Roberts John,
Han Xiaogang,
Hickman Dean,
Knutson Charles G.,
Kamm Roger D.
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970247
Subject(s) - microcirculation , biophysics , in vivo , interstitial fluid , capillary action , distribution (mathematics) , in vitro , diffusion , materials science , chemistry , biomedical engineering , biology , medicine , pathology , biochemistry , mathematical analysis , physics , mathematics , microbiology and biotechnology , radiology , composite material , thermodynamics
In article number 1902393, Charles G. Knutson, Roger D. Kamm, and co‐workers use microvascular networks self‐assembled from human cells within microfluid devices to directly measure trans‐capillary solute flux. Physiological fluid flow through the cell junctions, passive diffusion across the cell membrane, and active vesicular transport, recapitulate the in vivo mode and magnitude of transport for different types of therapeutic molecules.