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Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)
Author(s) -
Chen Ran,
Huang Hongxin,
Liu Hui,
Xi Jingyuan,
Ning Jing,
Zeng Wanjia,
Shen Congle,
Zhang Ting,
Yu Guangxin,
Xu Qiang,
Chen Xiangmei,
Wang Jie,
Lu Fengmin
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970205
Subject(s) - crispr , microvesicles , cas9 , genome editing , guide rna , gene , computational biology , hek 293 cells , biology , gene delivery , microbiology and biotechnology , exosome , genetic enhancement , endogeny , microrna , genetics , biochemistry
In article number 1902686, Jie Wang, Fengmin Lu, and co‐workers indicate the potential of exosomes as a safe and effective delivery vehicle of functional gRNA and Cas9 protein, and the exosomes‐mediated delivery of gene editing activity to adjacent and distant cells or tissues, which may further complicate the off‐target and safety concerns of the CRISPR/Cas9 system.