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Gene Therapy: Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8) (Small 36/2019)
Author(s) -
Poddar Arpita,
Conesa José J.,
Liang Kang,
Dhakal Sudip,
Reineck Philipp,
Bryant Gary,
Pereiro Eva,
Ricco Raffaele,
Amenitsch Heinz,
Doonan Christian,
Mulet Xavier,
Doherty Cara M.,
Falcaro Paolo,
Shukla Ravi
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970193
Subject(s) - metal organic framework , imidazolate , zeolitic imidazolate framework , gene delivery , drug delivery , nanotechnology , gene , dna , genetic enhancement , materials science , computational biology , chemistry , biology , biochemistry , organic chemistry , adsorption
Gene therapy utilizing non‐viral delivery systems still lags behind its viral counterpart despite being the safer method. In article number 1902268, Ravi Shukla and co‐workers explore the potential of metal–organic frameworks (MOFs) for gene delivery. The most fundamental aspect of DNA, its ability to translate into proteins, is investigated to determine the suitability of MOFs as delivery agents for gene therapy. The cover illustrates DNA embedded in the meshwork of ZIF‐8. Kate Rowe is acknowledged for framework photograph.