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Characterization Tools: Atom Probe Tomography for 3D Structural and Chemical Analysis of Individual Proteins (Small 24/2019)
Author(s) -
Sundell Gustav,
Hulander Mats,
Pihl Astrid,
Andersson Martin
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970130
Subject(s) - atom probe , characterization (materials science) , resolution (logic) , materials science , atom (system on chip) , silicon , amorphous solid , nanotechnology , oxide , chemical composition , tomography , silicon oxide , crystallography , chemistry , computer science , optics , optoelectronics , organic chemistry , physics , artificial intelligence , metallurgy , transmission electron microscopy , embedded system , silicon nitride
In article number 1900316, Martin Andersson and co‐workers develop a new method for protein structure analysis. Atom probe tomography (APT) is used to simultaneously asses the 3D structure and chemical composition of proteins with high resolution. The key concept of the method is to embed proteins in an amorphous silicon oxide glass, from which ultra‐sharp needles are prepared and analyzed with APT.