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Cancer Diagnostics: Quantitative and Specific Detection of Exosomal miRNAs for Accurate Diagnosis of Breast Cancer Using a Surface‐Enhanced Raman Scattering Sensor Based on Plasmonic Head‐Flocked Gold Nanopillars (Small 17/2019)
Author(s) -
Lee Jong Uk,
Kim Woo Hyun,
Lee Hye Sun,
Park Kyong Hwa,
Sim Sang Jun
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970091
Subject(s) - nanopillar , plasmon , oligonucleotide , raman scattering , materials science , deoxyribozyme , nanotechnology , nucleic acid , substrate (aquarium) , colloidal gold , raman spectroscopy , optoelectronics , dna , chemistry , nanoparticle , nanostructure , optics , biology , ecology , biochemistry , physics
In article number 1804968 , Kyong Hwa Park, Sang Jun Sim, and co‐workers develop a surface‐enhanced Raman scattering (SERS)‐based ultrasensitive exosomal miRNA detection platform with single‐nucleotide specificity, obtained by enhanced SERS signals from uniform plasmonic head‐flocked gold nanopillar SERS substrate that generates self‐assembled hot spots and enables hybridization between short oligonucleotides (i.e., miRNAs and locked nucleic acid probes).