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DNA Sensors: Transducing Protease Activity into DNA Output for Developing Smart Bionanosensors (Small 14/2019)
Author(s) -
Bui Hieu,
Brown Carl W.,
BuckhoutWhite Susan,
Díaz Sebastián A.,
Stewart Michael H.,
Susumu Kimihiro,
Oh Eunkeu,
Ancona Mario G.,
Goldman Ellen R.,
Medintz Igor L.
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970071
Subject(s) - cleave , dna , förster resonance energy transfer , proteases , protease , quantum dot , computation , nanotechnology , physics , chemistry , computer science , enzyme , materials science , biochemistry , algorithm , quantum mechanics , fluorescence
In article number 1805384 , Igor L. Medintz and co‐workers evaluate a protease to DNA output sensor. Peptide‐DNAs are assembled onto quantum dots as the input gate. Proteases cleave the peptide altering Förster resonance energy transfer efficiency with the quantum dot, freeing a DNA output to interact with a tetrahedral output gate. Converting sensor output to DNA sequences allows for information processing by DNA computation. Artistic rendition by Ella Maru.