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Cell Lysis: Piezoelectric Microchip for Cell Lysis through Cell–Microparticle Collision within a Microdroplet Driven by Surface Acoustic Wave Oscillation (Small 9/2019)
Author(s) -
Wang Shicai,
Lv Xiaoqing,
Su Yue,
Fan Zhiyuan,
Fang Weihao,
Duan Jiazhi,
Zhang Shan,
Ma Baojin,
Liu Feng,
Chen Hongda,
Geng Zhaoxin,
Liu Hong
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970050
Subject(s) - lysis , cell , intracellular , surface acoustic wave , microparticle , cell membrane , materials science , oscillation (cell signaling) , biophysics , nanotechnology , chemistry , microbiology and biotechnology , acoustics , optics , biology , physics , biochemistry
In article number 1804593 , Zhaoxin Geng, Hong Liu, and co‐workers introduce a cell lysis method in a surface acoustic wave (SAW) microchip. When a biofluid droplet containing cells and microparticles is dropped on the working microchip, the cell membrane function is disrupted by the SAW. The intracellular contents are released after cell lysis, which can be used in disease diagnosis and stem cell therapy research.