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Protein Nanoparticles: A Novel Self‐Assembled Mitochondria‐Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer (Small 2/2019)
Author(s) -
Zhu XinJie,
Li RiFei,
Xu Liang,
Yin Hui,
Chen Long,
Yuan Ye,
Zhong Wu,
Lin Jian
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201970010
Subject(s) - mitochondrion , nanoparticle , reactive oxygen species , apoptosis , in vivo , in vitro , cancer cell , cancer , chemistry , nanotechnology , biophysics , microbiology and biotechnology , materials science , biochemistry , biology , genetics
In article number 1803428 , Jian Lin and co‐workers report the discovery of a novel self‐assembled metal protein nanoparticle, designated GST‐MT‐3, which targets the mitochondria of cancer cells within 30 min in vitro and rapidly accumulates in tumors within 1 h in vivo. The little men carrying the bombs represent GST‐MT3 protein nanoparticles loading the cobalt ions. Through the blood vessels they accumulate in tumor regions rapidly. Meanwhile, they target the mitochondria and induce a reactive oxygen species storm, which eventually results in apoptosis of cancer cells.