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Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly
Author(s) -
Song Jingwen,
Yuan Chengqian,
Jiao Tifeng,
Xing Ruirui,
Yang Mengyao,
Adams Dave J.,
Yan Xuehai
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201907309
Subject(s) - antimicrobial , broad spectrum , self healing hydrogels , bacteria , drug delivery , biomolecule , bioavailability , chemistry , drug , nanotechnology , bacterial cell structure , antimicrobial peptides , membrane , biophysics , combinatorial chemistry , materials science , biochemistry , biology , pharmacology , organic chemistry , genetics
There is a real need for new antibiotics against self‐evolving bacteria. One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimicrobial biometallohydrogels based on the self‐assembly and local mineralization of Ag + ‐coordinated Fmoc‐amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram‐negative ( Escherichia coli ) and Gram‐positive ( Staphylococcus aureus ) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications.