Premium
Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR‐II Luminescent Nanodots
Author(s) -
Mateos Sergio,
Lifante José,
Li Chunyan,
Ximendes Erving C.,
MuñozOrtiz Tamara,
Yao Jingke,
FuenteFernández María,
García Villalón Ángel Luis,
Granado Miriam,
Zabala Gutierrez Irene,
RubioRetama Jorge,
Jaque Daniel,
Ortgies Dirk H.,
Fernández Nuria
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201907171
Subject(s) - in vivo , myocardial infarction , biomedical engineering , nanodot , preclinical imaging , fluorescence lifetime imaging microscopy , materials science , ultrasound , molecular imaging , nanotechnology , medicine , fluorescence , cardiology , radiology , optics , biology , microbiology and biotechnology , physics
Fast and precise localization of ischemic tissues in the myocardium after an acute infarct is required by clinicians as the first step toward accurate and efficient treatment. Nowadays, diagnosis of a heart attack at early times is based on biochemical blood analysis (detection of cardiac enzymes) or by ultrasound‐assisted imaging. Alternative approaches are investigated to overcome the limitations of these classical techniques (time‐consuming procedures or low spatial resolution). As occurs in many other fields of biomedicine, cardiological preclinical imaging can also benefit from the fast development of nanotechnology. Indeed, bio‐functionalized near‐infrared‐emitting nanoparticles are herein used for in vivo imaging of the heart after an acute myocardial infarct. Taking advantage of the superior acquisition speed of near‐infrared fluorescence imaging, and of the efficient selective targeting of the near‐infrared‐emitting nanoparticles, in vivo images of the infarcted heart are obtained only a few minutes after the acute infarction event. This work opens an avenue toward cost‐effective, fast, and accurate in vivo imaging of the ischemic myocardium after an acute infarct.