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A Microfluidic Ion Sensor Array
Author(s) -
Wu Chunxiao,
Selberg John,
Nguyen Brian,
Pansodtee Pattawong,
Jia Manping,
Dechiraju Harika,
Teodorescu Mircea,
Rolandi Marco
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201906436
Subject(s) - microfluidics , multielectrode array , microelectrode , membrane , electrolyte , nanotechnology , ion , ionic bonding , biosensor , materials science , ion channel , biophysics , chemistry , electrode , biochemistry , biology , organic chemistry , receptor
A balanced concentration of ions is essential for biological processes to occur. For example, [H + ] gradients power adenosine triphosphate synthesis, dynamic changes in [K + ] and [Na + ] create action potentials in neuronal communication, and [Cl − ] contributes to maintaining appropriate cell membrane voltage. Sensing ionic concentration is thus important for monitoring and regulating many biological processes. This work demonstrates an ion‐selective microelectrode array that simultaneously and independently senses [K + ], [Na + ], and [Cl − ] in electrolyte solutions. To obtain ion specificity, the required ion‐selective membranes are patterned using microfluidics. As a proof of concept, the change in ionic concentration is monitored during cell proliferation in a cell culture medium. This microelectrode array can easily be integrated in lab‐on‐a‐chip approaches to physiology and biological research and applications.