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Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo
Author(s) -
Yang Feifei,
Medik Yusra,
Li Liantao,
Tian Xi,
Fu Dong,
Brouwer Kim L. R.,
Wagner Kyle,
Sun Bo,
Sendi Hossein,
Mi Yu,
Wang Andrew Z.
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201906360
Subject(s) - translation (biology) , drug , drug delivery , nanomedicine , chemistry , nanotechnology , small molecule , pharmacology , liver injury , nanoparticle , medicine , materials science , biochemistry , messenger rna , gene
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical‐stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of nanotherapeutics beyond the intrinsic hepatotoxicity of nanoparticles (NPs) are poorly understood. Because of this knowledge gap, clinical translation efforts have avoided hepatotoxic molecules. By examining the hepatotoxicity of nanoformulations of known hepatotoxic compounds, it is demonstrated that nanotherapeutics are associated with lower hepatotoxicity than their small‐molecule counterparts. It is also found that the reduced hepatotoxicity is related to the uptake of nanotherapeutics by macrophages in the liver. These findings can facilitate further development and clinical translation of nanotherapeutics.