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Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment
Author(s) -
Chen Mengwei,
Wu Jiaojiao,
Ning Peng,
Wang Jingjing,
Ma Zuan,
Huang Liqun,
Plaza Gustavo R.,
Shen Yajing,
Xu Chang,
Han Yu,
Lesniak Maciej S.,
Liu Zhongmin,
Cheng Yu
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201905424
Subject(s) - cancer cell , mitochondrion , in vivo , cancer , materials science , nanotechnology , brain cancer , in vitro , adhesion , biophysics , microbiology and biotechnology , cancer research , chemistry , biology , biochemistry , composite material , genetics
In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria‐targeted zinc‐doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep‐seated tumors in a spatiotemporal fashion.