Premium
Biodegradable Bi 2 O 2 Se Quantum Dots for Photoacoustic Imaging‐Guided Cancer Photothermal Therapy
Author(s) -
Xie Hanhan,
Liu Mingqiang,
You Baihao,
Luo Guanghong,
Chen Yue,
Liu Bilu,
Jiang Zhenyou,
Chu Paul K.,
Shao Jundong,
Yu XueFeng
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201905208
Subject(s) - photothermal therapy , materials science , nanomaterials , photoacoustic imaging in biomedicine , quantum dot , in vivo , nanotechnology , aqueous solution , nanoparticle , cancer therapy , cancer , chemistry , optics , medicine , physics , microbiology and biotechnology , biology
As new 2D layered nanomaterials, Bi 2 O 2 Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top‐down approach for the synthesis of Bi 2 O 2 Se quantum dots (QDs) in a solution is described. The Bi 2 O 2 Se QDs with a size of 3.8 nm and thickness of 1.9 nm exhibit a high photothermal conversion coefficient of 35.7% and good photothermal stability. In vitro and in vivo assessments demonstrate that the Bi 2 O 2 Se QDs possess excellent photoacoustic (PA) performance and photothermal therapy (PTT) efficiency. After systemic administration, the Bi 2 O 2 Se QDs accumulate passively in tumors enabling efficient PA imaging of the entire tumors to facilitate imaging‐guided PTT without obvious toxicity. Furthermore, the Bi 2 O 2 Se QDs which exhibit degradability in aqueous media not only have sufficient stability during in vivo circulation to perform the designed therapeutic functions, but also can be discharged harmlessly from the body afterward. The results reveal the great potential of Bi 2 O 2 Se QDs as a biodegradable multifunctional agent in medical applications.