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Stereotactic Photodynamic Therapy Using a Two‐Photon AIE Photosensitizer
Author(s) -
He Xiaojing,
Situ Bo,
Gao Meng,
Guan Shujuan,
He Bairong,
Ge Xiaoxue,
Li Shiwu,
Tao Maliang,
Zou Hang,
Tang Ben Zhong,
Zheng Lei
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201905080
Subject(s) - photodynamic therapy , photosensitizer , two photon excitation microscopy , in vivo , materials science , absorption (acoustics) , ablation , reactive oxygen species , photochemistry , chemistry , fluorescence , optics , medicine , physics , biology , biochemistry , microbiology and biotechnology , organic chemistry , composite material
Two‐photon photodynamic therapy (TP‐PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation‐induced emission (AIE) feature, namely DPASP, for TP‐PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two‐photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two‐photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high‐precision is also successfully demonstrated. All these merits make DPASP a promising TP‐PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.