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Nanoparticle‐Embedded Electrospun Fiber–Covered Stent to Assist Intraluminal Photodynamic Treatment of Oesophageal Cancer
Author(s) -
Xiao Junyuan,
Cheng Liang,
Fang Tonglei,
Zhang Yiran,
Zhou Jia,
Cheng Ruoyu,
Tang Wantao,
Zhong Xiaoyan,
Lu Yong,
Deng Lianfu,
Cheng Yingsheng,
Zhu Yueqi,
Liu Zhuang,
Cui Wenguo
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201904979
Subject(s) - photodynamic therapy , stent , cancer , materials science , electrospinning , drug delivery , stage (stratigraphy) , nanoparticle , biomedical engineering , medicine , nanotechnology , radiology , chemistry , polymer , biology , paleontology , organic chemistry , composite material
Drug‐eluting stents (DESs) are promising candidates for treating human oesophageal cancer. However, the use of DESs to assist photodynamic therapy (PDT) of orthotopic oesophageal tumors is not yet demonstrated to the best of current knowledge. Herein, through an electrospinning technology it is shown that oxygen‐producing manganese dioxide nanoparticles are embedded into elelctrospun fibers, which are subsequently covered onto stents. Upon implantation, the nanoparticles are gradually released from the fibers and then diffuse into the nearby tumor tissue. Then, the hypoxic microenvironment can be effectively alleviated by reaction of MnO 2 with the endogenous H 2 O 2 within the tumor. After demonstrating the excellent PDT efficacy of the stents in a conventional subcutaneous mouse tumor model, such stents are further used for PDT treatment in a rabbit orthotopic oesophageal cancer model by inserting an optical fiber into the tumor site. Greatly prolonged survival of rabbits is observed after such intraluminal PDT treatment. Taken together, this work shows that the fiber‐covered stent as a nanoparticle delivery platform can enable effective PDT as a noninvasive treatment method for patients with advanced‐stage oesophageal cancer.