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Oxidase‐Like Fe‐N‐C Single‐Atom Nanozymes for the Detection of Acetylcholinesterase Activity
Author(s) -
Wu Yu,
Jiao Lei,
Luo Xin,
Xu Weiqing,
Wei Xiaoqian,
Wang Hengjia,
Yan Hongye,
Gu Wenling,
Xu Bo Z.,
Du Dan,
Lin Yuehe,
Zhu Chengzhou
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201903108
Subject(s) - catalysis , biosensor , chemistry , acetylcholinesterase , combinatorial chemistry , selectivity , radical , oxidase test , metal , nanotechnology , enzyme , materials science , organic chemistry , biochemistry
Abstract Single‐atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe‐N‐C SACs can mimic oxidase by activating O 2 into reactive oxygen species, O 2 − • radicals. Taking advantages of this property, single‐atom nanozymes (SAzymes) can become a great impetus to develop novel biosensors. Herein, the performance of Fe‐N‐C SACs as oxidase‐like nanozymes is explored. Besides, the Fe‐N‐C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Moreover, this SAzymes‐based biosensor is further used for monitoring the amounts of organophosphorus compounds.