Premium
Photoactivated Trifunctional Platinum Nanobiotics for Precise Synergism of Multiple Antibacterial Modes
Author(s) -
Deng Tian,
Zhao Hao,
Shi Miusi,
Qiu Yun,
Jiang Shuting,
Yang Xiangliang,
Zhao Yanbing,
Zhang Yufeng
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201902647
Subject(s) - photothermal therapy , platinum , photodynamic therapy , reactive oxygen species , antimicrobial , photothermal effect , escherichia coli , platinum nanoparticles , antibacterial activity , staphylococcus aureus , chemistry , combinatorial chemistry , biophysics , materials science , nanotechnology , bacteria , biochemistry , biology , catalysis , organic chemistry , genetics , gene
Integrating multiple strategies of antibacterial mechanisms into one has been proven to have tremendous promise for improving antimicrobial efficiency. Hence, dual‐valent platinum nanoparticles (dvPtNPs) with a zero‐valent platinum core (Pt 0 ) and bi‐valent platinum shell (Pt 2+ ions), combining photothermal and photodynamic therapy, together with “chemotherapy,” emerge as spatiotemporally light‐activatable platinum nano‐antibiotics. Under near‐infrared (NIR) exposure, the multiple antibacterial modes of dvPtNPs are triggered. The Pt 0 core reveals significant hyperthermia via effective photothermal conversion while an immediate release of chemotherapeutic Pt 2+ ions occurs through hyperthermia‐initiated destabilization of metallic interactions, together with reactive oxygen species (ROS) level increase, thereby resulting in synergistic antibacterial effects. The precise cooperative effects between photothermal, photodynamic, and Pt 2+ antibacterial effects are achieved on both Gram‐negative Escherichia coli and Gram‐positive methicillin‐resistant Staphylococcus aureus , where bacterial viability and colony‐forming units are significantly reduced. Moreover, similar results are observed in mice subcutaneous abscess models. Significantly, after NIR treatment, dvPtNP exhibits a more robust bacteria‐killing efficiency than other PtNP groups, owing to its integration of dramatic damage to the bacterial membrane and DNA, and alteration to ATP and ROS metabolism. This study broadens the avenues for designing and synthesizing antibacterial materials with higher efficiency.