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Depriving Bacterial Adhesion‐Related Molecule to Inhibit Biofilm Formation Using CeO 2 ‐Decorated Metal‐Organic Frameworks
Author(s) -
Qiu Hao,
Pu Fang,
Liu Zhengwei,
Deng QingQing,
Sun Panpan,
Ren Jinsong,
Qu Xiaogang
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201902522
Subject(s) - biofilm , bacteria , extracellular polymeric substance , adhesion , reactive oxygen species , microbiology and biotechnology , adenosine triphosphate , chemistry , extracellular , cell adhesion , biophysics , nanotechnology , biology , biochemistry , materials science , genetics , organic chemistry
The formation of bacterial biofilm is one of the causes of antimicrobial resistance, often leading to persistent infections and a high fatality rate. Therefore, there is an urgent need to develop novel and effective strategies to inhibit biofilm formation. Adenosine triphosphate (ATP) plays an important role in bacterial adhesion and biofilm formation through stimulating cell lysis and extracellular DNA (eDNA) release. Herein, a simple and robust strategy for inhibiting biofilm formation is developed using CeO 2 ‐decorated porphyrin‐based metal‐organic frameworks (MOFs). The function of extracellular ATP (eATP) can be inhibited by CeO 2 nanoparticles, leading to the disruption of the initial adhesion of bacteria. Furthermore, planktonic bacteria can be killed by cytotoxic reactive oxygen species (ROS) generated by MOFs. As a consequence, the synergic effect of eATP deprivation and ROS generation presents excellent capacity to prevent biofilm formation, which may provide a new direction for designing flexible and effective biofilm‐inhibiting systems.