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Integrating Fluorinated Polymer and Manganese‐Layered Double Hydroxide Nanoparticles as pH‐activated 19 F MRI Agents for Specific and Sensitive Detection of Breast Cancer
Author(s) -
Zhang Cheng,
Li Li,
Han Felicity Y.,
Yu Xinying,
Tan Xiao,
Fu Changkui,
Xu Zhi Ping,
Whittaker Andrew K.
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201902309
Subject(s) - nanoparticle , hydroxide , manganese , aqueous solution , materials science , magnetic nanoparticles , in vivo , reducing agent , dissolution , nuclear chemistry , chemistry , nuclear magnetic resonance , nanotechnology , inorganic chemistry , organic chemistry , physics , microbiology and biotechnology , metallurgy , biology
19 F magnetic resonance imaging ( 19 F MRI) agents capable of being activated upon interactions with cancer triggers are attracting increasing attention, although challenges still remain for precise and specific detection of cancer tissues. In this study, a novel hybrid 19 F MRI agent for pH‐sensitive detection of breast cancer tissues is reported, a composite system designed by conjugating a perfluoropolyether onto the surface of manganese‐incorporated layered double hydroxide (Mn‐LDH@PFPE) nanoparticles. The 19 F NMR/MRI signals from aqueous solutions of Mn‐LDH@PFPE nanoparticles are quenched at pH 7.4, but “turned on” following a reduction in pH to below 6.5. This is due to partial dissolution of Mn 2+ from the Mn‐LDH nanoparticles and subsequent reduction in the effect of paramagnetic relaxation. Significantly, in vivo experiments reveal that an intense 19 F MR signal can be detected only in the breast tumor tissue after intravenous injection of Mn‐LDH@PFPE nanoparticles due to such a specific activation. Thus pH‐activated Mn‐LDH@PFPE nanoparticles are a potential “smart” 19 F MRI agent for precise and specific detection of cancer diseases.