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New Advances in In Vivo Applications of Gated Mesoporous Silica as Drug Delivery Nanocarriers
Author(s) -
GarcíaFernández Alba,
Aznar Elena,
MartínezMáñez Ramón,
Sancenón Félix
Publication year - 2020
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201902242
Subject(s) - nanocarriers , drug delivery , nanotechnology , mesoporous silica , mesoporous material , materials science , supramolecular chemistry , in vivo , mass transport , scaffold , porosity , computer science , chemistry , biochemical engineering , molecule , organic chemistry , engineering , microbiology and biotechnology , composite material , biology , catalysis , database
One appealing concept in the field of hybrid materials is related to the design of gated materials. These materials are prepared in such a way that the release of chemical or biochemical species from voids of porous supports to a solution is triggered upon the application of external stimuli. Such gated materials are mainly composed of two subunits: i) a porous inorganic scaffold in which a cargo is stored, and ii) certain molecular or supramolecular entities, grafted onto the external surface, that can control mass transport from the interior of the pores. On the basis of this concept, a large number of examples are developed in the past ten years. A comprehensive overview of gated materials used in drug delivery applications in in vivo models from 2016 to date is thus given here.