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Aggregation‐Induced Electrochemiluminescence by Metal‐Binding Protein Responsive Hydrogel Scaffolds
Author(s) -
Jiang Hui,
Qin Zhaojian,
Zheng Youkun,
Liu Liu,
Wang Xuemei
Publication year - 2019
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201901170
Subject(s) - biomolecule , linker , self healing hydrogels , nanoclusters , electrochemiluminescence , biomaterial , nanotechnology , chemistry , bivalent (engine) , biophysics , combinatorial chemistry , materials science , metal , detection limit , polymer chemistry , computer science , organic chemistry , chromatography , biology , operating system
Functionalized hydrogels have aroused general interest due to their versatile applications in biomaterial fields. This work reports a hydrogel network composed of gold nanoclusters linked with bivalent cations such as Ca 2+ , Mg 2+ , and Zn 2+ . The hydrogel exhibits both aggregation‐induced emission (AIE) and aggregation‐induced electrochemiluminescence (AIECL) effects. Most noteworthy, the AIECL effect (≈50‐fold enhancement) is even more significant than the corresponding AIE effect (approximately fivefold enhancement). Calmodulin, a Ca 2+ binding protein, may efficiently regulate the AIECL dynamics after specific binding of the Ca 2+ linker, with the linear range from 0.3 to 50 µg mL −1 and a limit of detection of 0.1 µg mL −1 . Considering the important roles of bivalent cations in the life system, these results may pave a new avenue for the design of a biomolecule‐responsive AIECL‐type hydrogel with multifunctional biomedical purposes.